PEScience High Volume

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We all love pumps, right? That skin-splitting, cell-swelling feeling makes even the most humble of gym-goers feel like they’re on top of the world. What if I told you that there’s a product out there that can aid you in your quest for the biggest pump you’ve ever attained? Before we get into that, let’s take a brief look at the science behind the muscle pump and why it’s important in building muscle.




Nitric Oxide: The King of Pumps and Vascularity

Nitric oxide (NO) is a molecule produced endogenously within the body that signals the relaxation of smooth muscle cells within arteries and blood vessels. When the body senses a rise in blood pressure, the shear stress against the endothelial (innermost) wall of arteries initiates a biological pathway that leads to NO production. Once the pathway has been stimulated, NO travels to the cells within the smooth muscle of blood vessels and signals them to relax and allow more blood to travel more efficiently throughout the body and into working muscles.

So why would we want increased NO production during weight training?

Relaxed and dilated blood vessels means that more oxygenated, nutrient-rich blood can reach working muscles. Not only is this important for bigger looking pumps, but it is also vital to keeping the muscle saturated with oxygen and nutrient-rich blood to help fuel work capacity and recovery. Maximizing your pump may just be the solution to bringing your training sessions to the next level and aiding you in building the physique of your dreams.


PEScience’s High Volume Pre-Workout Nitric Oxide Enhancer: The Solution for Better Pumps

PEScience’s product, High Volume, may just be exactly what you were looking for. High Volume contains some of the most effective ingredients on the market for increasing NO production and fueling crazy pumps. So what exactly is in High Volume that makes it so effective? Let’s take a look at the winning formula.


L-Citrulline: Rightfully Taking L-Arginine’s Place

For a long time L-Arginine was thought to be the end-all-be-all for increasing NO production. New research has shown us that arginine may not be as effective as we once thought. Citrulline has impressed researchers and scientists time and time again in labs and human trials, earning the title as “the pump amino acid”. Studies have shown that citrulline produces NO more effectively than arginine, so it makes sense to include citrulline in your pump stack!



Arginine Nitrate: Even More NO

While citrulline helps boost NO, arginine nitrate can help further NO production. There comes a point in the NO production process where the body reaches a point of diminishing return, or a “saturation point”. In simple terms, this is when no more citrulline can be used and NO production is “maxed out”. This is where arginine nitrate comes in. Nitrates act as an NO donor in the nitrate-nitrite-nitric oxide pathway, therefore bypassing the enzyme called eNOS (endothelial nitric oxide synthase), which is used in the citrulline-nitric oxide mechanism. What does this suggest for the user? Heightened NO and long lasting pumps!


Agmatine Sulfate: The New Kid on the Block

Although agmatine sulfate has little to no research in humans, there are studies showing the vasodilating properties of the compound in animal trials. Research is suggesting that agmatine works with NOS (nitric oxide synthase, the enzyme that breaks down nitric oxide), and helps to further enhance NO production.


AmentoPump® Amentoflavone: Contractions and Vasodilation

Amentoflavone has been blowing up lately based on the research showing that this compound has the ability to enhance muscle contraction and dilate blood vessels. With respect to muscle contraction, amentoflavone has been shown to activate calcium ion channels that lead to more calcium in the muscle. In muscle cells, calcium binds to proteins that are elemental in muscle contraction. More calcium in the muscle means that your muscles will have a better ability to contract. With regards to vasodilation, amentoflavone is a phosphodiesterase (breaks down cAMP) inhibitor, therefore increasing cAMP levels. This pathway has been shown to increase smooth muscle relaxation in blood vessels. Like you have already learned, relaxed blood vessels means more blood flow and crazy pumps!


HydroMax® Glycerol and Taurine: Engorged, Hyper-hydrated Muscles

HydroMax® glycerol and taurine work via different mechanisms than the latter compounds. Glycerol Monostearate (GMS) has been used for years by bodybuilders and athletes looking to achieve hyper-hydrated states, increased endurance, and/or a “full” physique. Unfortunately, GMS has become outdated and also has a relatively poor shelf-life. High Volume includes a superior form of glycerol silica entitled HydroMax®, which works by affecting osmolarity and greatly increasing fluid volume within blood and muscle tissue. HydroMax® also allows the body to hold more water; this means that the user will not only achieve full, hydrated muscles, but will also experience a lowered internal body temperature. Basically, wherever HyrdroMax® goes, water follows. The same goes for taurine. Taurine works as an osmolyte (a compound that affects osmosis), and plays a role in maintaining fluid balance and cellular fluid volume.


Rutaecarpine: Heating Up Your Training

Rutaecarpine is a compound that works as an agonist (activator) of the vanilloid receptors that are located on the plasma membranes of several human cell types. Vanilloid receptors are responsible for temperature sensation, which is the reason why rutaecarpine is used as a “warming” agent in Chinese medicine.

As you can see, High Volume is a great formula that can be used to fuel some of the craziest pumps you have ever experienced. Between the nitric oxide enhancing ingredients and the hyper-hydrating effects of HydroMax® glycerol, there is no question that High Volume will give you that skin-splitting pump that is coveted by every bodybuilder and physique enthusiast out there.



1. Luminiţa Jerca, Oltiţa Jerca, Gabriela Mancaş, Irina Constantinescu, R.Lupuşoru. “Mechanism of Action and Biochemical Effects of Nitric Oxide.” The Journal of Preventative Medicine 2002; 10 (2): 35-45. Web

2. MacAllister, Raymond J. “Arginine and Nitrate Tolerance.” British Journal of Pharmacology 2000; 130.2 209–210. Web.

3. Yuqi Gao, Bulent Gumusel, Gabor Koves, Anand Prasad, Qingzhong Hao, ‘Albert Hyman, and Howard Lippton. “Agmatine: A Novel Endogenous Vasodilator Substance.” Journal of Life Sciences 1995; 57 (8): 83-86. Web.

4. Suzuki, A. et al. “Properties of Amentoflavone, a Potent Caffeine-like Ca2+ Releaser in Skeletal Muscle Sarcoplasmic Reticulum.” European Journal of Pharmacology 1999 May 7;372(1):97-102. Web.

5. Ross, Megan LR et al. “Effects of Lowering Body Temperature via Hyperhydration, with and without Glycerol Ingestion and Practical Precooling on Cycling Time Trial Performance in Hot and Humid Conditions.” Journal of the International Society of Sports Nutrition 9012: 55. PMC. Web.

6. Ripps, Harris, and Wen Shen. “Review: Taurine: A ‘very Essential’ Amino Acid.” Molecular Vision 18 2012: 2673–2686. Web.

7. Kobayashi Y, Nakano Y, Kizaki M, Hoshikuma K, Yokoo Y, Kamiya T. “Capsaicin-like anti-obese activities of evodiamine from fruits of Evodia rutaecarpa, a vanilloid receptor agonist.” Planta Med 2001 Oct;67(7):628-33. Web.

8. Jeremy Bartos, PhD. “Hydromax® Glycerol Powder 65%: A Uniquely Optimized, Highly Concentrated Powdered Form of Glycerol Delivering Next-level Hydration and Next-gen Product Potential.” Glanbia Nutritionals. 2014 Aug. Web.

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